In pharmacology, medicines we choose to call high dose medicines are typically dosed at milligram(mg) or microgram (mcg) levels, which are 1,000 to 1,000,000 times higher than doses described as nanodoses. Nanodose medicines are often administered in concentrations which are at nanogram (ng) or picogram (pg) levels.

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In most high dose medicines, the central tenets are (1) more is better when treating the target until (2) an upper dose demonstrates toxic effects in other organ systems and/or no increased benefit in treating the the target organ.

 

In the world of nanodosing, (1) less may be more effective when treating the target provided that (2) enough medicine is provided to have a stimulative effect on the target and not too much is provided to induce high dose inhibition.